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Reviewer Instructions:
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We would appreciate your assistance in the peer review of this manuscript. Please read the paper carefully and include your comments on this form. Please select your recommendation regarding publication from the drop down list, and rate the paper on a scale 0-100 (optional).

1. Reviewer Blind Comments to Author:

Please include specific, detailed comments regarding the originality, scientific quality, relevance to the field of this journal, and presentation. Check the need for tables and figures, and the adequacy of the references. Please be as specific as possible, and indicate why a paper is (un)acceptable and what is required to make it acceptable. Authors especially appreciate it if you cite references supporting your comments.

2. Reviewer Confidential Comments to Editor:

Please include any confidential comments you wish to make. Make sure that these are consistent with your comments to the author.


For each question, please use the following scale to answer (place an x in the space provided): 

"To what extent does the article meet this criterion?"

0	Fails by a large amount
1	Fails by a small amount
2	Succeeds by a small amount
3	Succeeds by a large amount
4	Not applicable

The subject addressed in this article is worthy of investigation.

The information presented was new.

The conclusions were supported by the data.

Is there a financial or other conflict of interest between your work and that of the authors?

Please note that your recommendation and reviewer report are expected to cover the Highlights and Graphical Abstract if submitted with the manuscript.


Please give a frank account of the strengths and weaknesses of the article: