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Course info
KAZ / TOXI
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Course description
Department/Unit / Abbreviation
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KAZ
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TOXI
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Academic Year
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2023/2024
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Academic Year
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2023/2024
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Title
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Toxicology
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Form of course completion
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Exam
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Form of course completion
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Exam
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Accredited / Credits
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Yes,
3
Cred.
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Type of completion
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Combined
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Type of completion
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Combined
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Time requirements
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Lecture
2
[Hours/Week]
Tutorial
1
[Hours/Week]
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Course credit prior to examination
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Yes
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Course credit prior to examination
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Yes
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Automatic acceptance of credit before examination
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Yes in the case of a previous evaluation 4 nebo nic.
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Included in study average
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YES
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Language of instruction
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-
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Occ/max
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Automatic acceptance of credit before examination
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Yes in the case of a previous evaluation 4 nebo nic.
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Summer semester
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0 / -
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0 / -
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0 / -
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Included in study average
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YES
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Winter semester
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21 / -
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0 / -
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0 / -
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Repeated registration
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NO
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Repeated registration
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NO
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Timetable
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Yes
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Semester taught
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Winter semester
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Semester taught
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Winter semester
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Minimum (B + C) students
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10
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Optional course |
Yes
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Optional course
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Yes
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Language of instruction
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-
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Internship duration
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0
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No. of hours of on-premise lessons |
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Evaluation scale |
1|2|3|4 |
Periodicity |
každý rok
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Evaluation scale for credit before examination |
S|N |
Periodicita upřesnění |
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Fundamental theoretical course |
No
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Fundamental course |
Yes
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Fundamental theoretical course |
No
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Evaluation scale |
1|2|3|4 |
Evaluation scale for credit before examination |
S|N |
Substituted course
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None
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Preclusive courses
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N/A
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Prerequisite courses
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N/A
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Informally recommended courses
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N/A
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Courses depending on this Course
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N/A
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Histogram of students' grades over the years:
Graphic PNG
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XLS
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Course objectives:
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Students will be familiar with problems of toxicology, poisoning symptoms and examination methods in toxicology.
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Requirements on student
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Active participation in lessons, written credit test, oral examination.
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Content
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Lectures: 1. Toxicology. Introduction, history, sub-disciplines (clinical, industrial, experimental, etc..). Resources and applications of toxicology. 2. Poisons. Definition, classification, labeling, dose-effect, toxicokinetics (entry, metabolism, excretion). 3. Types of materials. Sampling dates, treatment before analysis (isolation, extraction, separation, mineralization etc.). 4. Toxicological examination. The reasons, known - unknown exposure, screening, biological exposure tests - BET, the choice of the investigated substance according to the time of exposure, interpretation (maximum permissible limit, NPK). 5. Analytical techniques. Principles of quantitative methods (spectrophotometry, chromatography, immunochemical methods etc.). 6. Poisoning by agents blocking the oxygen transfer. 7. Poisoning by alcohols (ethanol, methanol, ethylene glycol). 8. Poisoning by heavy metals, solvents, "-icides" (herbicides, pesticides, fungicides), rarer types of poisoning. 9. Poisoning by substances from the life and domestic environment (plants, animals, chemist goods, medicinal products). 10. Drug levels monitoring (TDM), the pharmacokinetic evaluation. 11. Drugs and abused substances. Classification of groups and effects, screening, conventional drugs - new drugs. Laboratory practicals: 1. Principles on the safety in the toxicological laboratory, instruments and equipment. 2. - 3. The biological material - types, quantity, method of preservation, processing time, documentation. 4. - 5. Adjustments of samples, deproteinization, extraction, hydrolysis, isolation mineralization. 6. Analytical methods in toxicology - immunochemical. 7. Analytical Methods in toxicology - chromatographic (TLC, GC, HPLC). 8. Analytical methods in toxicology - spectrophotometric (AAS, UV-VIS, IR). 9. Organization of work in a toxicological laboratory, toxicological analysis in the mode POCT, excursion to the lab. 10. Issues of the forensic toxicology (collection and preservation of material, accredited methods, apparatus equipment of the laboratory). 11. Written credit exam.
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Activities
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Fields of study
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Guarantors and lecturers
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Guarantors:
Prof. MUDr. Jaroslav Racek, DrSc. (100%),
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Lecturer:
Prof. MUDr. Jaroslav Racek, DrSc. (100%),
Ing. Václav Senft (100%),
Ing. Ladislav Trefil (100%),
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Tutorial lecturer:
Prof. MUDr. Jaroslav Racek, DrSc. (100%),
Ing. Václav Senft (100%),
Ing. Ladislav Trefil (100%),
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Literature
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Basic:
Balíková, M. Forenzní a klinická toxikologie. Galén, Praha 2004.
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Basic:
Lincová, D., Farghali, H. Základní a aplikovaná farmakologie. Galén, Praha 2006.
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Recommended:
Katzung, B., G. Basic and Clinical Pharmacology. Lange medical books. McGrawn-Hill, 2007.
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Recommended:
Racek, J. a kol. Klinická biochemie. Galén, Praha, Karolinum, 2006.
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On-line library catalogues
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Time requirements
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All forms of study
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Activities
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Time requirements for activity [h]
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Contact hours
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33
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Preparation for formative assessments (2-20)
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2
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Preparation for an examination (30-60)
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45
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Total
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80
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Prerequisites
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Knowledge - students are expected to possess the following knowledge before the course commences to finish it successfully: |
No particular prerequisites specified. |
Skills - students are expected to possess the following skills before the course commences to finish it successfully: |
No particular prerequisites specified. |
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Learning outcomes
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Knowledge - knowledge resulting from the course: |
The graduate will be able to carry out examinations of toxic substances in biological samples using selected analytical techniques. |
- definuje toxickou látku a klasifikuje otravy podle působící noxy a příznaků
- vyjmenuje druhy toxikologických vyšetření
- interpretuje toxikologická vyšetření, zná nejvyšší přípustné limity.
- prokazuje širokou znalost o technikách odběru vzorku a úpravách před analýzou (izolace, extrakce, separace, mineralizace aj.).
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Skills - skills resulting from the course: |
- realizuje vyšetření toxické látky v biologickém materiálu pomocí vybraných analytických technik (imunochemických, chromatografických, spektrofotometrických). |
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Assessment methods
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Knowledge - knowledge achieved by taking this course are verified by the following means: |
Oral exam |
Test |
Skills - skills achieved by taking this course are verified by the following means: |
Skills demonstration during practicum |
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Teaching methods
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Knowledge - the following training methods are used to achieve the required knowledge: |
Lecture |
Skills - the following training methods are used to achieve the required skills: |
Practicum |
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